Journal of Toxicological Studies

Due to the ubiquitous occurrence in the aquatic environment and terrestrial ecosystem and underlying eco-environmental risks, nano/microplastics (NPs/MPs) have sparked great public concerns. The purpose of this work is aimed to summarize the harmful influence of NPs/MPs on reproduction and offspring health and further explore the potential mechanisms of action, thereby facilitating the more comprehensive understanding of NPs/MPs features. Literature search databases included EMBASE, Web of Science, and PubMed. The study selection and data extraction were implemented according to the inclusion criteria. NPs/MPs could accumulate and trigger reproductive toxic responses and thereafter generate deleterious effects on the offspring health. Accordingly, the reproductive toxicity of NPs/MPs was characterized as the sperm deformity, decline in sperm count and motility, follicular growth tardiness, ovarian fibrosis, granulosa cell death, disorder of reproductive hormone secretion, as well as the fetal growth restriction, glycolipid metabolism disorder, and inflammatory responses of the next generation. Additionally, mechanism research revealed that NPs/MPs exposure brought about inflammatory responses and oxidative stress and thereafter, destroyed the blood-testis barrier (BTB) integrity, motivated spermatogenic cell apoptosis by activating the JNK and p38/MAPK-Nrf2/NF-κB pathways, and induced ovarian granulosa cell pyroptosis and apoptosis and subsequent ovarian fibrosis via the Wnt/β-Catenin and NLRP3/Caspase-1 pathways. Nevertheless, this work also highlighted the imperative requirements for scientific and systematic risk assessments of NPs/MPs, so as to identify the feasible risk mitigation strategies.

Agrochemicals, while essential for increasing agricultural yields and pest control, have unintended consequences. They contaminate soil and water, disrupting ecosystems, reducing biodiversity, and threatening aquatic life. Furthermore, agrochemicals harm non-target organisms, disrupting ecological balance. On the human health front, farmworkers and pesticide applicators face acute poisoning risks, with symptoms ranging from discomfort to severe illness or death. Chronic health effects include links to cancer, neurological disorders, and reproductive problems, raising concerns about food safety and worker well-being. Addressing agrochemical toxicity requires a multifaceted approach. Governments must enforce strict regulations to minimize environmental contamination and ensure safe handling practices. The agricultural industry can adopt sustainable methods like integrated pest management (IPM) and organic farming to reduce reliance on agrochemicals. Innovations such as precision agriculture, biological pest control, nanotechnology, and artificial intelligence for early risk detection are essential. Collaboration among stakeholders is critical for a more sustainable and environmentally friendly agriculture sector, involving regulatory measures like maximum residue limits (MRLs) and sustainable practices like IPM and organic farming. In summary, this review highlights the urgent need to address agrochemical toxicity holistically, balancing agricultural productivity with environmental and health concerns to ensure a sustainable future for agriculture and the planet.

Heavy metals play essential roles in biological activities as enzyme cofactors in trace amounts. However, their significance is overshadowed by potential harm in excess. Bio-accumulation, toxicity, non-biodegradability, and persistence are hallmarks that impact the environment and human health. Bio-accumulation is critical as metals accumulate in organisms, posing risks in ecosystems, especially in the food chain. This leads to elevated metal concentrations in the human food chain. Even at trace levels, heavy metals like lead, mercury, cadmium, chromium, and arsenic exhibit toxicity, causing various health issues, emphasizing the need to regulate exposure. Non-biodegradability distinguishes heavy metals; they persist in the environment, enhancing the risks associated with prolonged exposure and accumulation. Due to their recognized toxicity, heavy metals are a focus of research. Understanding sources, pathways, and effects is crucial for effective mitigation strategies. Researchers explore pollution control, improved industrial practices, and remediation techniques. Anthropogenic activities, such as industrialization, urbanization, waste disposal, and agricultural practices, release heavy metals into the environment. This contaminates air, water, and soil, contributing to environmental and health risks. The present paper discusses the sources and toxicological effects of various heavy metals.