Study on biomimetic phospholipid modification of aliphatic polyester biomaterials

Abstract

Abstract: It is low feasibility using plasma energy particles to excite, ionize and break bonds molecules on the surface of aliphatic polyester biomaterials to produce new topological structures. The biomimetic phosphatidylcholine modification technology of aliphatic polyester biomaterials was studied. The phosphatidylcholine monomer [2 (methacryloxy) ethyl]phosphatidylcholine was synthesized by reaction of 2 chloro 1, 3, 2 dioxaphosphoric heterocyclic pentane with different raw material solutions; the phosphatidylcholine[2 (methacryloxy) ethyl]phosphatidylcholine, acrylonitrile and water were copolymerized to form PANCMPC; the phosphatidylcholine [2 (methacryloxy) ethyl]phosphatidylcholine was replaced by PANCMPC, and PANCHEMA was obtained by repeated copolymerization. PANCHEMA was reacted with 2 chloro 2 oxygen 1, 3, 2 dioxophosphorus heterocyclic pentane, and then opened with trimethylamine to form biomimetic phospholipid modified PLCANCP. Experiments show that the proposed technology has good hydrophilicit