Experimental study of new bionic bone in repairing goat skull defects

Abstract

Objective In order to verify the biological safety and the effect of inducing osteogenesis of two different proportions of collagen based biomimetic bone materials, the model of goat skull defect was designed. Methods First, we used trephine to make circular defect in goat skull, then the bionic bones with different proportions of collagen were implanted into the defect areas. Finally, the inflammatory response and osteogenesis in the bone defect areas were observed after implantation. Results Most of the A group materials with high collagen content were mostly degraded and partly induced into bone, while the B group with low collagen content was not degraded and had no effect on bone formation. After the two groups of materials were implanted into the goats, there were no inflammatory reactions, which meant that the collagen based biomimetic bone material had good biocompatibility. Conclusions The collagen based biomimetic bone material has good biocompatibility, good biodegradability, and a certain effect on bone formation